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Long-term melatonin use increases heart failure risk by 90%

Preliminary study links chronic melatonin use to nearly double the risk of heart failure over five years

Daniele Morais
August 29, 2026 · 3 min read
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Long-term melatonin use increases heart failure risk by 90%
Photo: "Enitan Bababunmi Science Laboratory, Faculty of Science, Lagos State University" by Official alade is licensed under CC BY-SA 4.0. To view a copy of this license, visit https://cr

A large-scale preliminary study has found that individuals with chronic insomnia who use melatonin for extended periods have an approximately 90% higher risk of developing heart failure over a five-year period.

What the research indicates

The data point to an association between the continuous consumption of melatonin supplements and a significant increase in the likelihood of heart failure. The increased risk was calculated in comparison to people who do not use the compound to improve sleep.

Limitations and interpretations

Although the relationship is statistically relevant, the study does not establish cause and effect between melatonin and heart problems. The authors emphasize that the results do not prove that melatonin causes heart failure, but they suggest the need for further investigation into the safety of long-term supplement use.

Implications for melatonin users

For those who rely on melatonin as a sleep aid, the finding raises questions about the prudence of maintaining its use for extended periods without medical supervision. The general recommendation remains to consult healthcare professionals before starting or prolonging the use of any supplement.

  • Study focused on patients with chronic insomnia.
  • Nearly doubled risk of heart failure over five years.
  • Preliminary results, without proof of causality.
  • Need for further research to confirm long-term safety.

With information from ScienceDaily.

Source: ScienceDaily

#melatonin#insomnia#cardiovascular health#supplements#heart risk
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